Gd3+ Doped CoFe2O4 Nanoparticles for Targeted Drug Delivery and Magnetic Resonance Imaging

Nanoparticles of CoGdxFe2 ? xO4 (x = 0%, 25%, 50%) synthesized via sol–gel auto combustion technique and encapsulated within a polymer (Eudragit E100) shell containing curcumin by single emulsion solvent evaporation were formulated in this study. Testing nanoparticles was carried out using different characterization techniques, to investigate composition, crystallinity, size, morphology, surface charge, functional groups magnetic properties the samples. The increased hydrophilicity resulted sustained drug release 90.6% 95% for E1(CoGd0.25Fe1.75O4) E2(CoGd0.50Fe1.5O4), respectively, over time span 24 h. relaxivities best-chosen samples measured 3T resonance imaging (MRI) machine, high r2/r1 ratio 43.64 23.34 composition E2(CoGd0.50Fe1.5O4) suggests their ability work as better T2 contrast agent. Thus, these novel nanostructures cannot only enable MRI diagnosis but also targeted delivery.